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Best Cruises out of San Diego, California
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7-night mexico cruise
$591
9% Off
Royal Caribbean –
Serenade of the Seas
Departs
Apr 25, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$419
Royal Caribbean –
Serenade of the Seas
Departs
Jan 03, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$449
Royal Caribbean –
Serenade of the Seas
Departs
Jan 28, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$489
Royal Caribbean –
Serenade of the Seas
Departs
Feb 28, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$549
Royal Caribbean –
Serenade of the Seas
Departs
Mar 28, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$199
Royal Caribbean –
Serenade of the Seas
Departs
Jan 10, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$199
Royal Caribbean –
Serenade of the Seas
Departs
Jan 14, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$199
Royal Caribbean –
Serenade of the Seas
Departs
Jan 17, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$199
Royal Caribbean –
Serenade of the Seas
Departs
Jan 21, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$199
Royal Caribbean –
Serenade of the Seas
Departs
Jan 24, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
3-night mexico cruise
$279
Royal Caribbean –
Serenade of the Seas
Departs
Feb 04, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$249
Royal Caribbean –
Serenade of the Seas
Departs
Feb 07, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
3-night mexico cruise
$279
Royal Caribbean –
Serenade of the Seas
Departs
Feb 11, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
4-night mexico cruise
$289
Royal Caribbean –
Serenade of the Seas
Departs
Feb 14, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$279
Royal Caribbean –
Serenade of the Seas
Departs
Feb 18, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
4-night mexico cruise
$249
Royal Caribbean –
Serenade of the Seas
Departs
Feb 21, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$289
Royal Caribbean –
Serenade of the Seas
Departs
Feb 25, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
4-night mexico cruise
$309
Royal Caribbean –
Serenade of the Seas
Departs
Mar 07, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$289
Royal Caribbean –
Serenade of the Seas
Departs
Mar 11, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
4-night mexico cruise
$352
18% Off
Royal Caribbean –
Serenade of the Seas
Departs
Mar 14, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$319
Royal Caribbean –
Serenade of the Seas
Departs
Mar 18, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$349
Royal Caribbean –
Serenade of the Seas
Departs
Mar 21, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$319
Royal Caribbean –
Serenade of the Seas
Departs
Mar 25, 2027
from
San Diego, California
Up to 5 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$549
Royal Caribbean –
Serenade of the Seas
Departs
Nov 15, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$190
Royal Caribbean –
Serenade of the Seas
Departs
Nov 29, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
Cruises from San Diego, California
Cruises from San Diego are a wonderful option for guests departing from the West Coast. Offering varied itineraries for cruisers both regionally and out-of-state, visitors sailings from this North America Departure Port are also convenient – as before or after your San Diego cruise, you can explore the city’s unique attractions. Popular destinations that you can visit on cruises from San Diego include Mexico, Hawaii, and more!