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Best Cruises out of San Diego, California
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7-night mexico cruise
$556
6% Off
Royal Caribbean –
Serenade of the Seas
Departs
Oct 18, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$888
Royal Caribbean –
Serenade of the Seas
Departs
Nov 22, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$938
6% Off
Royal Caribbean –
Serenade of the Seas
Departs
Dec 20, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$1,091
3% Off
Royal Caribbean –
Serenade of the Seas
Departs
Dec 27, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$415
Royal Caribbean –
Serenade of the Seas
Departs
Feb 21, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$717
Royal Caribbean –
Serenade of the Seas
Departs
Feb 28, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$713
5% Off
Royal Caribbean –
Serenade of the Seas
Departs
Mar 28, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$733
7% Off
Royal Caribbean –
Serenade of the Seas
Departs
Apr 25, 2027
from
San Diego, California
Up to 3 deals
including an Avoya Exclusive
Avoya Exclusive Rate
7-night mexico cruise
$649
Royal Caribbean –
Serenade of the Seas
Departs
Oct 04, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$641
Royal Caribbean –
Serenade of the Seas
Departs
Oct 25, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
2-night mexico cruise
$337
Royal Caribbean –
Serenade of the Seas
Departs
Oct 02, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$485
19% Off
Royal Caribbean –
Serenade of the Seas
Departs
Oct 11, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$437
15% Off
Royal Caribbean –
Serenade of the Seas
Departs
Oct 15, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$601
Royal Caribbean –
Serenade of the Seas
Departs
Nov 01, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$601
Royal Caribbean –
Serenade of the Seas
Departs
Nov 08, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$599
Royal Caribbean –
Serenade of the Seas
Departs
Nov 15, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$432
Royal Caribbean –
Serenade of the Seas
Departs
Nov 29, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$377
Royal Caribbean –
Serenade of the Seas
Departs
Dec 03, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$411
Royal Caribbean –
Serenade of the Seas
Departs
Dec 06, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
3-night mexico cruise
$348
Royal Caribbean –
Serenade of the Seas
Departs
Dec 10, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$599
Royal Caribbean –
Serenade of the Seas
Departs
Dec 13, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$631
Royal Caribbean –
Serenade of the Seas
Departs
Jan 03, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$434
Royal Caribbean –
Serenade of the Seas
Departs
Jan 10, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
3-night mexico cruise
$404
Royal Caribbean –
Serenade of the Seas
Departs
Jan 14, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$415
Royal Caribbean –
Serenade of the Seas
Departs
Jan 17, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Cruises from San Diego, California
Cruises from San Diego are a wonderful option for guests departing from the West Coast. Offering varied itineraries for cruisers both regionally and out-of-state, visitors sailings from this North America Departure Port are also convenient – as before or after your San Diego cruise, you can explore the city’s unique attractions. Popular destinations that you can visit on cruises from San Diego include Mexico, Hawaii, and more!