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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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3-night south america cruise
$423
56% Off List
MSC Cruises –
MSC Musica
Departs
Mar 29, 2027
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$359
MSC Cruises –
MSC Virtuosa
Departs
Mar 31, 2027
from
MACEIO
4-night south america cruise
$977
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 06, 2026
from
Santos, Brazil
Up to 2 deals
1-night south america cruise
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MSC Cruises –
MSC Preziosa
Departs
Apr 02, 2026
from
Santos, Brazil