Menu
Call
No Avoya Fees on Cruises or Tours. Click Here!
Home
cruises to south america

MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

Showing 101-125 of 208 results
Meet Natalie Thompson, one of Avoya's trusted travel advisors.
Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.
Choose your adventure and let us handle the rest.
Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.
Help Me Plan
7-night south america cruise
$1,349
MSC Cruises – MSC Seaview
4.6 (5)
Departs Jan 31, 2027 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
4-night south america cruise
$589
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 01, 2027 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,329
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 01, 2027 from CAMBORIU
Up to 3 deals including an Avoya Exclusive
9-night south america cruise
$1,740
45% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 01, 2027 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$931
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 02, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,276
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 02, 2027 from Salvador, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,407
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 03, 2027 from MACEIO
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,438
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 04, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
9-night south america cruise
$2,009
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 04, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,031
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 06, 2027 from Paranagua, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,109
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 06, 2027 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,031
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 07, 2027 from ITAJAI
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,399
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 07, 2027 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,399
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 08, 2027 from CAMBORIU
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,016
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 09, 2027 from Salvador, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,082
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 09, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,060
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 10, 2027 from MACEIO
Up to 4 deals including an Avoya Exclusive
9-night south america cruise
$1,606
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 10, 2027 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,388
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 11, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$851
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 13, 2027 from Paranagua, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,085
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 13, 2027 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
9-night south america cruise
$1,917
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 13, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$851
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 14, 2027 from ITAJAI
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,349
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 14, 2027 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
4-night south america cruise
$589
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 15, 2027 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
Don't Miss the Latest Deals!
Talk to a Vacation Planner
Avoya Travel Logo Mark
Why Choose Avoya?
U.S. / Canada:
1-888-447-8459

International: +1-760-305-5070
Avoya Travel.
CST: 2085569-40
Fla. Seller of Travel Ref. No. ST36781
© Avoya Travel®. All Rights Reserved.
Avoya Travel Logo