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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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3-night south america cruise
$521
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
4-night south america cruise
$569
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
7-night south america cruise
$1,037
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$329
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
4-night south america cruise
$475
58% Off List
MSC Cruises –
MSC Musica
Departs
Dec 06, 2026
from
Santos, Brazil
Up to 2 deals
6-night south america cruise
$679
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
7-night south america cruise
$811
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,012
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 08, 2026
from
Salvador, Brazil
Up to 2 deals
6-night south america cruise
$721
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 09, 2026
from
Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$981
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 09, 2026
from
MACEIO
Up to 2 deals
3-night south america cruise
$447
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 10, 2026
from
Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,142
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 11, 2026
from
Buenos Aires, Argentina
Up to 2 deals
7-night south america cruise
$811
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 12, 2026
from
Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$849
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 12, 2026
from
Santos, Brazil
Up to 2 deals
4-night south america cruise
$475
58% Off List
MSC Cruises –
MSC Musica
Departs
Dec 13, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$811
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 13, 2026
from
ITAJAI
Up to 2 deals
3-night south america cruise
$453
49% Off List
MSC Cruises –
MSC Divina
Departs
Dec 15, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$811
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 15, 2026
from
Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$970
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 15, 2026
from
Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,012
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 16, 2026
from
MACEIO
Up to 2 deals
3-night south america cruise
$435
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 17, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,071
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 19, 2026
from
Paranagua, Brazil
Up to 2 deals
8-night south america cruise
$1,089
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 19, 2026
from
Buenos Aires, Argentina
Up to 2 deals
7-night south america cruise
$1,159
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 19, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,071
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 20, 2026
from
ITAJAI
Up to 2 deals