No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. No Avoya Fees on Cruises or Tours.
Click Here!
No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. No Avoya Fees on Cruises or Tours.
Click Here!
MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
51-75 of
170
results
Meet Natalie Thompson, one of Avoya's trusted travel
advisors.
Our team has helped more than 2.5 million travelers save
time, save money, and book their perfect vacation.
Choose your adventure and let us handle the rest.
Your dedicated Personal Travel Advisor is here to help you plan
the vacation of your dreams. From finding the best price to
answering every question, we are with you every step of the way
at no extra cost.
7-night south america cruise
$1,832
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 29, 2026
from
Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,108
MSC Cruises –
MSC Seaview
Departs
Dec 31, 2026
from
Buenos Aires, Argentina
8-night south america cruise
$2,461
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 31, 2026
from
Rio de Janeiro, Brazil
Up to 3 deals
3-night south america cruise
$592
50% Off List
MSC Cruises –
MSC Divina
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 3 deals
4-night south america cruise
$689
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,289
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,409
MSC Cruises –
MSC Seaview
Departs
Jan 03, 2027
from
Santos, Brazil
7-night south america cruise
$1,009
MSC Cruises –
MSC Seaview
Departs
Jan 04, 2027
from
CAMBORIU
7-night south america cruise
$1,264
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 05, 2027
from
Salvador, Brazil
Up to 3 deals
9-night south america cruise
$1,716
49% Off List
MSC Cruises –
MSC Splendida
Departs
Jan 05, 2027
from
Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,211
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 06, 2027
from
MACEIO
Up to 3 deals
7-night south america cruise
$1,448
MSC Cruises –
MSC Seaview
Departs
Jan 07, 2027
from
Buenos Aires, Argentina
9-night south america cruise
$2,135
49% Off List
MSC Cruises –
MSC Splendida
Departs
Jan 08, 2027
from
Rio de Janeiro, Brazil
Up to 3 deals
7-night south america cruise
$1,236
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 09, 2027
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,009
MSC Cruises –
MSC Seaview
Departs
Jan 10, 2027
from
Santos, Brazil
7-night south america cruise
$1,469
MSC Cruises –
MSC Seaview
Departs
Jan 11, 2027
from
CAMBORIU
7-night south america cruise
$1,211
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 12, 2027
from
Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,264
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 13, 2027
from
MACEIO
Up to 3 deals
7-night south america cruise
$978
MSC Cruises –
MSC Seaview
Departs
Jan 14, 2027
from
Buenos Aires, Argentina
9-night south america cruise
$1,716
49% Off List
MSC Cruises –
MSC Splendida
Departs
Jan 14, 2027
from
Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,289
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 16, 2027
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$939
MSC Cruises –
MSC Seaview
Departs
Jan 17, 2027
from
Santos, Brazil
7-night south america cruise
$1,047
47% Off List
MSC Cruises –
MSC Musica
Departs
Jan 17, 2027
from
ITAJAI
Up to 3 deals
9-night south america cruise
$2,037
49% Off List
MSC Cruises –
MSC Splendida
Departs
Jan 17, 2027
from
Rio de Janeiro, Brazil
Up to 3 deals
7-night south america cruise
$939
MSC Cruises –
MSC Seaview
Departs
Jan 18, 2027
from
CAMBORIU