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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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7-night south america cruise
$1,107
49% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 14, 2026
from
Santos, Brazil
Up to 2 deals
8-night south america cruise
$2,494
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Mar 14, 2026
from
Montevideo, Uruguay
Up to 3 deals
7-night south america cruise
$1,040
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 15, 2026
from
Santos, Brazil
Up to 3 deals
8-night south america cruise
$2,370
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Mar 15, 2026
from
Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,147
47% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 17, 2026
from
Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,049
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 18, 2026
from
MACEIO
Up to 2 deals
7-night south america cruise
$1,431
29% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 19, 2026
from
Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,120
49% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 21, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,261
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 22, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,067
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 24, 2026
from
Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,505
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 25, 2026
from
MACEIO
Up to 2 deals
7-night south america cruise
$763
MSC Cruises –
MSC Seaview
Departs
Mar 28, 2026
from
Santos, Brazil
Up to 2 deals
4-night south america cruise
$917
50% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 29, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,049
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 31, 2026
from
Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,468
MSC Cruises –
MSC Seaview
Departs
Apr 01, 2026
from
MACEIO
Up to 2 deals
7-night south america cruise
$1,024
MSC Cruises –
MSC Seaview
Departs
Apr 04, 2026
from
Santos, Brazil
Up to 2 deals
4-night south america cruise
$475
58% Off List
MSC Cruises –
MSC Musica
Departs
Nov 16, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$423
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 20, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$383
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 23, 2026
from
Santos, Brazil
Up to 2 deals
4-night south america cruise
$569
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 26, 2026
from
Santos, Brazil
Up to 2 deals
4-night south america cruise
$585
50% Off List
MSC Cruises –
MSC Divina
Departs
Nov 29, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$363
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 30, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$509
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 02, 2026
from
Santos, Brazil
Up to 2 deals
3-night south america cruise
$383
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 03, 2026
from
Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,142
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 03, 2026
from
Buenos Aires, Argentina
Up to 2 deals