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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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4-night south america cruise
$475
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 13, 2026
from
Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,389
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 14, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$475
49% Off List
MSC Cruises –
MSC Divina
Departs
Dec 15, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$981
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 15, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,024
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 16, 2026
from
MACEIO
Up to 1 deal
3-night south america cruise
$463
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 17, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,385
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 19, 2026
from
Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,612
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 19, 2026
from
Buenos Aires, Argentina
Up to 1 deal
8-night south america cruise
$1,392
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 20, 2026
from
Santos, Brazil
Up to 1 deal
5-night south america cruise
$894
50% Off List
MSC Cruises –
MSC Divina
Departs
Dec 21, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,360
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 22, 2026
from
Salvador, Brazil
Up to 1 deal
9-night south america cruise
$1,939
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 22, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$629
MSC Cruises –
MSC Virtuosa
Departs
Dec 23, 2026
from
MACEIO
Up to 1 deal
3-night south america cruise
$538
50% Off List
MSC Cruises –
MSC Divina
Departs
Dec 26, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,834
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 26, 2026
from
Santos, Brazil
Up to 1 deal
9-night south america cruise
$2,145
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 27, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,832
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 29, 2026
from
Salvador, Brazil
Up to 1 deal
8-night south america cruise
$2,039
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 31, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$592
50% Off List
MSC Cruises –
MSC Divina
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$797
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,289
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,264
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 05, 2027
from
Salvador, Brazil
Up to 1 deal
9-night south america cruise
$1,716
49% Off List
MSC Cruises –
MSC Splendida
Departs
Jan 05, 2027
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,211
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 06, 2027
from
MACEIO
Up to 1 deal
8-night south america cruise
$1,320
50% Off List
MSC Cruises –
MSC Musica
Departs
Jan 06, 2027
from
Santos, Brazil
Up to 1 deal