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cruises to south america

MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

Showing 26-50 of 208 results
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7-night south america cruise
$1,328
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 10, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
8-night south america cruise
$1,752
46% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 11, 2026 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$995
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 12, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
4-night south america cruise
$525
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 13, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,349
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 13, 2026 from Santos, Brazil
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$1,349
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 14, 2026 from CAMBORIU
Up to 3 deals including an Avoya Exclusive
8-night south america cruise
$1,602
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 14, 2026 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
3-night south america cruise
$475
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 15, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,062
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 15, 2026 from Salvador, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,252
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 16, 2026 from MACEIO
Up to 4 deals including an Avoya Exclusive
3-night south america cruise
$463
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 17, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,508
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 17, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,361
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 19, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
8-night south america cruise
$1,740
46% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
6-night south america cruise
$839
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 20, 2026 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,469
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 20, 2026 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
5-night south america cruise
$894
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 21, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,469
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 21, 2026 from CAMBORIU
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,031
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 22, 2026 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,360
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 22, 2026 from Salvador, Brazil
Up to 4 deals including an Avoya Exclusive
9-night south america cruise
$1,923
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 22, 2026 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
3-night south america cruise
$437
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 23, 2026 from MACEIO
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$1,498
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 24, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
3-night south america cruise
$580
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 26, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
7-night south america cruise
$1,857
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 26, 2026 from Santos, Brazil
Up to 4 deals including an Avoya Exclusive
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