No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. No Avoya Fees.
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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. No Avoya Fees.
Click Here!
MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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3-night south america cruise
$408
49% Off List
MSC Cruises –
MSC Musica
Departs
Nov 23, 2026
from
Santos, Brazil
Up to 3 deals
4-night south america cruise
$526
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 26, 2026
from
Santos, Brazil
Up to 3 deals
3-night south america cruise
$469
49% Off List
MSC Cruises –
MSC Musica
Departs
Nov 30, 2026
from
Santos, Brazil
Up to 3 deals
3-night south america cruise
$408
49% Off List
MSC Cruises –
MSC Musica
Departs
Dec 03, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,079
48% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
Up to 3 deals
4-night south america cruise
$535
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 06, 2026
from
Santos, Brazil
Up to 3 deals
3-night south america cruise
$468
40% Off List
MSC Cruises –
MSC Musica
Departs
Dec 10, 2026
from
Santos, Brazil
Up to 3 deals
4-night south america cruise
$535
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 13, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,186
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 15, 2026
from
Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,056
48% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 16, 2026
from
MACEIO
Up to 3 deals
3-night south america cruise
$638
49% Off List
MSC Cruises –
MSC Musica
Departs
Dec 17, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,399
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 19, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,219
MSC Cruises –
MSC Musica
Departs
Dec 20, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,036
MSC Cruises –
MSC Musica
Departs
Dec 22, 2026
from
Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,869
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 26, 2026
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,413
MSC Cruises –
MSC Musica
Departs
Dec 29, 2026
from
Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,846
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 29, 2026
from
Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,006
MSC Cruises –
MSC Musica
Departs
Jan 02, 2027
from
Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$1,319
48% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,019
MSC Cruises –
MSC Musica
Departs
Jan 03, 2027
from
ITAJAI
Up to 2 deals
7-night south america cruise
$1,006
MSC Cruises –
MSC Musica
Departs
Jan 05, 2027
from
Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,256
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Jan 06, 2027
from
MACEIO
Up to 3 deals
7-night south america cruise
$1,006
MSC Cruises –
MSC Musica
Departs
Jan 09, 2027
from
Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$1,019
MSC Cruises –
MSC Musica
Departs
Jan 10, 2027
from
ITAJAI
Up to 2 deals
7-night south america cruise
$1,026
MSC Cruises –
MSC Musica
Departs
Jan 12, 2027
from
Rio de Janeiro, Brazil
Up to 2 deals