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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
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7-night south america cruise
$2,083
43% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 22, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,742
48% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 25, 2026
from
MACEIO
7-night south america cruise
$1,532
MSC Cruises –
MSC Seaview
Departs
Mar 28, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$1,060
50% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 29, 2026
from
Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,138
MSC Cruises –
MSC Seaview
Departs
Apr 04, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$429
MSC Cruises –
MSC Divina
Departs
Nov 12, 2026
from
Salvador, Brazil
Up to 1 deal
1-night south america cruise
$99
MSC Cruises –
MSC Divina
Departs
Nov 15, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$623
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 20, 2026
from
Santos, Brazil
Up to 1 deal
3-night south america cruise
$393
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 23, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$569
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 26, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$479
MSC Cruises –
MSC Virtuosa
Departs
Nov 28, 2026
from
Salvador, Brazil
Up to 1 deal
4-night south america cruise
$585
50% Off List
MSC Cruises –
MSC Divina
Departs
Nov 29, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,309
49% Off List
MSC Cruises –
MSC Splendida
Departs
Nov 29, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
1-night south america cruise
$109
MSC Cruises –
MSC Virtuosa
Departs
Dec 01, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$719
34% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 02, 2026
from
Santos, Brazil
Up to 1 deal
3-night south america cruise
$482
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 03, 2026
from
Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,392
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 03, 2026
from
Buenos Aires, Argentina
Up to 1 deal
3-night south america cruise
$521
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$689
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,037
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,479
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 06, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,012
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 08, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$970
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 09, 2026
from
MACEIO
Up to 1 deal
3-night south america cruise
$457
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 10, 2026
from
Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,142
50% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 11, 2026
from
Buenos Aires, Argentina
Up to 1 deal