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cruises to south america

MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

Showing 1-25 of 320 results
4-night south america cruise
$726
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Nov 24, 2025 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$628
48% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Nov 25, 2025 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$892
69% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Nov 29, 2025 from Santos, Brazil
Up to 1 deal
4-night south america cruise
$635
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 01, 2025 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,829
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 02, 2025 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,754
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 03, 2025 from MACEIO
Up to 1 deal
3-night south america cruise
$545
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 05, 2025 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$935
69% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 06, 2025 from Santos, Brazil
Up to 1 deal
3-night south america cruise
$676
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Dec 07, 2025 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$2,290
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 09, 2025 from Montevideo, Uruguay
Up to 2 deals
3-night south america cruise
$574
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 12, 2025 from Santos, Brazil
Up to 1 deal
3-night south america cruise
$857
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 14, 2025 from Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,037
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 15, 2025 from Santos, Brazil
Up to 1 deal
6-night south america cruise
$905
58% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 16, 2025 from Salvador, Brazil
Up to 1 deal
3-night south america cruise
$988
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Dec 16, 2025 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$839
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 17, 2025 from Rio de Janeiro, Brazil
Up to 2 deals
8-night south america cruise
$1,910
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 17, 2025 from Montevideo, Uruguay
Up to 2 deals
4-night south america cruise
$1,132
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Dec 19, 2025 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$2,145
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 19, 2025 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,465
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 21, 2025 from ITAJAI
Up to 1 deal
7-night south america cruise
$1,465
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 22, 2025 from Santos, Brazil
Up to 1 deal
6-night south america cruise
$959
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Dec 23, 2025 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$2,293
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Dec 25, 2025 from Rio de Janeiro, Brazil
Up to 1 deal
10-night south america cruise
$3,423
50% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 25, 2025 from Montevideo, Uruguay
Up to 2 deals
8-night south america cruise
$2,407
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Dec 26, 2025 from Santos, Brazil
Up to 1 deal
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