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MSC Cruises to Africa

MSC Cruises Africa cruises are diverse and exciting, exploring everything from ancient pyramids in Egypt to guided safaris in natural reserves. Onboard the MSC Sinfonia, which sails all of MSC Cruise line’s African Cruises, guests will enjoy distinct Italian style, comfortable accommodations, countless activities, and more. In addition, on all MSC Cruises to Africa, kids sail free!

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5-night africa cruise
$697
50% Off List
MSC Cruises – MSC Opera
4.0 (5)
Departs Apr 04, 2026 from Cape Town, South Africa
Up to 2 deals
7-night africa cruise
$720
5% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 05, 2026 from Santa Cruz de Tenerife, Spain
Up to 4 deals including an Avoya Exclusive
9-night africa cruise
$877
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 12, 2026 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
10-night africa cruise
$1,043
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 12, 2026 from Santa Cruz de Tenerife, Spain
Up to 4 deals including an Avoya Exclusive
8-night africa cruise
$1,097
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 12, 2026 from Santa Cruz de Tenerife, Spain
Up to 4 deals including an Avoya Exclusive
3-night africa cruise
$453
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Nov 27, 2026 from Durban, South Africa
Up to 1 deal
4-night africa cruise
$553
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Nov 30, 2026 from Durban, South Africa
Up to 1 deal
6-night africa cruise
$415
50% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 07, 2026 from Rome (Civitavecchia), Italy
Up to 4 deals including an Avoya Exclusive
8-night africa cruise
$555
50% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 07, 2026 from Rome (Civitavecchia), Italy
Up to 4 deals including an Avoya Exclusive
4-night africa cruise
$566
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 07, 2026 from Durban, South Africa
Up to 1 deal
11-night africa cruise
$761
48% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 07, 2026 from Rome (Civitavecchia), Italy
Up to 4 deals including an Avoya Exclusive
10-night africa cruise
$789
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 07, 2026 from Rome (Civitavecchia), Italy
Up to 2 deals
3-night africa cruise
$467
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 11, 2026 from Durban, South Africa
Up to 1 deal
7-night africa cruise
$833
48% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 13, 2026 from Santa Cruz de Tenerife, Spain
Up to 4 deals including an Avoya Exclusive
4-night africa cruise
$619
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 14, 2026 from Durban, South Africa
Up to 1 deal
7-night africa cruise
$1,140
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 15, 2026 from Funchal, Madeira Islands, Portugal
Up to 4 deals including an Avoya Exclusive
7-night africa cruise
$1,176
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 17, 2026 from Lanzarote, Spain
Up to 4 deals including an Avoya Exclusive
3-night africa cruise
$533
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 18, 2026 from Durban, South Africa
Up to 1 deal
7-night africa cruise
$976
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 18, 2026 from Las Palmas, Spain
Up to 4 deals including an Avoya Exclusive
7-night africa cruise
$1,020
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 20, 2026 from Santa Cruz de Tenerife, Spain
Up to 4 deals including an Avoya Exclusive
5-night africa cruise
$875
50% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 21, 2026 from Durban, South Africa
Up to 1 deal
7-night africa cruise
$1,059
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 22, 2026 from Funchal, Madeira Islands, Portugal
Up to 4 deals including an Avoya Exclusive
7-night africa cruise
$1,371
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 24, 2026 from Lanzarote, Spain
Up to 4 deals including an Avoya Exclusive
7-night africa cruise
$1,150
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Dec 25, 2026 from Las Palmas, Spain
Up to 4 deals including an Avoya Exclusive
12-night africa cruise
$2,184
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Dec 26, 2026 from Durban, South Africa
Up to 1 deal
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