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Best South America Cruises

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9-night south america cruise
$2,651
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Feb 16, 2026 from Montevideo, Uruguay
Up to 3 deals
3-night south america cruise
$743
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Feb 17, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,033
MSC Cruises – MSC Armonia
3.2 (19)
Departs Feb 17, 2026 from MACEIO
Up to 1 deal
7-night south america cruise
$1,263
42% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 17, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,205
54% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Feb 18, 2026 from Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,515
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 18, 2026 from MACEIO
Up to 2 deals
4-night south america cruise
$909
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Feb 20, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,049
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 21, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,071
51% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Feb 21, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
7-night south america cruise
$1,139
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Feb 22, 2026 from Santos, Brazil
Up to 3 deals
3-night south america cruise
$691
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Feb 24, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,101
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 24, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,132
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 25, 2026 from MACEIO
Up to 2 deals
7-night south america cruise
$1,163
50% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Feb 25, 2026 from Salvador, Brazil
Up to 3 deals
8-night south america cruise
$1,336
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Feb 25, 2026 from Buenos Aires, Argentina
Up to 2 deals
8-night south america cruise
$2,479
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Feb 25, 2026 from Montevideo, Uruguay
Up to 3 deals
8-night south america cruise
$1,924
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Feb 26, 2026 from Buenos Aires, Argentina
Up to 3 deals
4-night south america cruise
$759
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Feb 27, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,160
50% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Feb 28, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
7-night south america cruise
$1,288
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 28, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,066
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 01, 2026 from Santos, Brazil
Up to 3 deals
3-night south america cruise
$717
50% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Mar 03, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,112
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 03, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,316
44% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Mar 03, 2026 from MACEIO
Up to 3 deals
7-night south america cruise
$1,006
49% Off List
MSC Cruises – MSC Armonia
3.2 (19)
Departs Mar 04, 2026 from Salvador, Brazil
Up to 3 deals

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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