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Best South America Cruises

Showing 126-150 of 545 results
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12-night south america cruise
$3,549
50% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Mar 07, 2027 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
21-night south america cruise
$5,605
52% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Mar 19, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
14-night south america cruise
$2,540
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 16, 2028 from Buenos Aires, Argentina
Up to 1 deal
24-night south america cruise
$15,699
60% Off List
Regent Cruises – Seven Seas Splendor
4.3 (31)
Departs Feb 17, 2026 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
18-night south america cruise
$1,794
Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Secret Rate
15-night south america cruise
$3,322
Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
11-night south america cruise
$9,849
61% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 22, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
22-night south america cruise
$16,899
58% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Mar 09, 2027 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
16-night south america cruise
$12,899
59% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Mar 10, 2027 from Lima (Callao), Peru
Up to 4 deals including an Avoya Exclusive
14-night south america cruise
$1,520
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 05, 2027 from Buenos Aires, Argentina
Up to 1 deal
14-night south america cruise
$1,860
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 19, 2027 from Buenos Aires, Argentina
Up to 1 deal
14-night south america cruise
$2,458
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 02, 2028 from Buenos Aires, Argentina
Up to 1 deal
14-night south america cruise
$4,299
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Jan 05, 2028 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
14-night south america cruise
$4,399
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Jan 19, 2028 from Lima (Callao), Peru
Up to 3 deals including an Avoya Exclusive
30-night south america cruise
$22,449
62% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Jan 27, 2028 from Lima (Callao), Peru
Up to 3 deals including an Avoya Exclusive
14-night south america cruise
$2,540
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 30, 2028 from Buenos Aires, Argentina
Up to 1 deal
16-night south america cruise
$5,299
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Feb 02, 2028 from Punta Arenas, Chile
Up to 4 deals including an Avoya Exclusive
14-night south america cruise
$2,210
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 13, 2028 from Buenos Aires, Argentina
Up to 1 deal
21-night south america cruise
$6,999
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Feb 18, 2028 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
21-night south america cruise
$17,249
60% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Feb 26, 2028 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
16-night south america cruise
$2,059
Holland America – Oosterdam
4.2 (212)
Departs Nov 18, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
27-night south america cruise
$5,044
Holland America – Volendam
4.3 (73)
Departs Nov 25, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
11-night south america cruise
$8,080
Silversea – Silver Cloud
4.3 (16)
Departs Feb 27, 2027 from Puerto Williams, Chile
Up to 1 deal including an Avoya Exclusive
18-night south america cruise
$12,670
Silversea – Silver Nova
5.0 (5)
Departs Mar 05, 2027 from Santiago (Valparaiso), Chile
Up to 2 deals including an Avoya Exclusive
15-night south america cruise
$2,324
Holland America – Oosterdam
4.2 (212)
Departs Mar 09, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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