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Best South America Cruises

Showing 126-150 of 821 results
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22-night south america cruise
$7,075
Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 16, 2028 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
17-night south america cruise
$3,125
Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 21, 2028 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
25-night south america cruise
$19,899
59% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 07, 2029 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
17-night south america cruise
$14,999
59% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
25-night south america cruise
$20,999
61% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
8-night south america cruise
$7,099
63% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 18, 2029 from Santiago (Valparaiso), Chile
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$4,648
AmaWaterways – AmaMelodia
Departs Nov 18, 2026 from Cartagena, Colombia
Up to 2 deals
7-night south america cruise
$4,698
AmaWaterways – AmaMelodia
Departs Nov 25, 2026 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$6,998
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Nov 28, 2026 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$6,048
AmaWaterways – AmaMelodia
Departs Dec 02, 2026 from Cartagena, Colombia
Up to 2 deals
7-night south america cruise
$5,548
AmaWaterways – AmaMelodia
Departs Dec 23, 2026 from Barranquilla, Colombia
7-night south america cruise
$4,249
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Dec 26, 2026 from Barranquilla, Colombia
20-night south america cruise
$16,450
Silversea – Silver Nova
5.0 (5)
Departs Jan 18, 2027 from Bridgetown, Barbados
Up to 3 deals including an Avoya Exclusive
29-night south america cruise
$5,999
Holland America – Zaandam
4.5 (133)
Departs Feb 13, 2027 from Buenos Aires, Argentina
11-night south america cruise
$9,150
Silversea – Silver Cloud
4.3 (16)
Departs Feb 27, 2027 from Puerto Williams, Chile
Up to 3 deals including an Avoya Exclusive
15-night south america cruise
$2,774
Holland America – Oosterdam
4.2 (213)
Departs Mar 09, 2027 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
16-night south america cruise
$2,299
Holland America – Oosterdam
4.2 (213)
Departs Mar 24, 2027 from San Antonio, Chile
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$5,348
AmaWaterways – AmaMelodia
Departs Mar 31, 2027 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$4,448
AmaWaterways – AmaMelodia
Departs Apr 14, 2027 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$4,898
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 01, 2027 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$5,098
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 29, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,748
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 26, 2027 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$4,679
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 01, 2028 from Cartagena, Colombia
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$5,288
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 08, 2028 from Barranquilla, Colombia
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$4,779
AmaWaterways – AmaMelodia
Departs Jan 12, 2028 from Cartagena, Colombia
Up to 1 deal including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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