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Best South America Cruises

Showing 101-125 of 492 results
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14-night south america cruise
$4,549
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Jan 19, 2028 from Lima (Callao), Peru
Up to 4 deals including an Avoya Exclusive
17-night south america cruise
$3,199
Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 24, 2028 from Buenos Aires, Argentina
Up to 5 deals including an Avoya Exclusive
30-night south america cruise
$22,649
62% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Jan 27, 2028 from Lima (Callao), Peru
Up to 3 deals including an Avoya Exclusive
15-night south america cruise
$3,089
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Feb 01, 2028 from San Antonio, Chile
Up to 2 deals
16-night south america cruise
$5,299
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Feb 02, 2028 from Punta Arenas, Chile
Up to 5 deals including an Avoya Exclusive
15-night south america cruise
$3,009
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Feb 16, 2028 from Buenos Aires, Argentina
Up to 2 deals
21-night south america cruise
$6,699
50% Off List
Oceania Cruises – Sirena
4.3 (140)
Departs Feb 18, 2028 from Rio de Janeiro, Brazil
Up to 5 deals including an Avoya Exclusive
21-night south america cruise
$18,099
60% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Feb 26, 2028 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
15-night south america cruise
$3,339
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Mar 02, 2028 from San Antonio, Chile
Up to 2 deals
7-night south america cruise
$4,448
AmaWaterways – AmaMelodia
Departs Aug 05, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,348
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 03, 2026 from Barranquilla, Colombia
7-night south america cruise
$4,898
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 17, 2026 from Barranquilla, Colombia
Up to 1 deal
31-night south america cruise
$4,379
Holland America – Oosterdam
4.2 (212)
Departs Nov 18, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
30-night south america cruise
$4,699
Holland America – Volendam
4.3 (73)
Departs Nov 22, 2026 from New York City, New York
Up to 3 deals including an Avoya Exclusive
15-night south america cruise
$2,599
Holland America – Oosterdam
4.2 (212)
Departs Dec 04, 2026 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$4,798
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Dec 05, 2026 from Cartagena, Spain
Up to 1 deal
22-night south america cruise
$4,999
Holland America – Oosterdam
4.2 (212)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$4,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 02, 2027 from Cartagena, Spain
Up to 1 deal
41-night south america cruise
$10,284
Holland America – Zaandam
4.5 (132)
Departs Jan 03, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Avoya Exclusive Rate
22-night south america cruise
$5,099
Holland America – Oosterdam
4.2 (212)
Departs Jan 10, 2027 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
20-night south america cruise
$17,400
Silversea – Silver Nova
5.0 (5)
Departs Jan 18, 2027 from Bridgetown, Barbados
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$6,298
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 23, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,049
AmaWaterways – AmaMelodia
Departs Feb 03, 2027 from Barranquilla, Colombia
7-night south america cruise
$6,098
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Feb 06, 2027 from Barranquilla, Colombia
Up to 1 deal
10-night south america cruise
$12,500
Silversea – Silver Nova
5.0 (5)
Departs Feb 07, 2027 from Rio de Janeiro, Brazil
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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