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Best South America Cruises

Showing 76-100 of 545 results
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7-night south america cruise
$5,698
AmaWaterways – AmaMelodia
Departs Jan 13, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,998
AmaWaterways – AmaMelodia
Departs Jan 20, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$6,298
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 23, 2027 from Barranquilla, Colombia
Up to 1 deal
18-night south america cruise
$13,249
61% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 02, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
7-night south america cruise
$6,098
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Feb 06, 2027 from Barranquilla, Colombia
Up to 1 deal
21-night south america cruise
$6,330
52% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Feb 14, 2027 from Santiago (Valparaiso), Chile
Up to 4 deals including an Avoya Exclusive
Secret Rate
7-night south america cruise
$5,498
AmaWaterways – AmaMelodia
Departs Feb 17, 2027 from Barranquilla, Colombia
Up to 1 deal
18-night south america cruise
$13,999
60% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 20, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
7-night south america cruise
$5,198
AmaWaterways – AmaMelodia
Departs Mar 10, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,998
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 13, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,448
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 20, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,298
AmaWaterways – AmaMelodia
Departs Mar 24, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,099
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 27, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,348
AmaWaterways – AmaMelodia
Departs Mar 31, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,299
AmaWaterways – AmaMelodia
Departs Apr 07, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 10, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 14, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 21, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,799
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 24, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,799
AmaWaterways – AmaMelodia
Departs Apr 28, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 01, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,598
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 08, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 12, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 15, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,548
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 22, 2027 from Cartagena, Spain
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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