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Best South America Cruises

Showing 51-75 of 545 results
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7-night south america cruise
$3,399
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Sep 05, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,449
AmaWaterways – AmaMelodia
Departs Sep 09, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,798
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Sep 12, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,098
AmaWaterways – AmaMelodia
Departs Sep 16, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,448
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 03, 2026 from Barranquilla, Colombia
7-night south america cruise
$3,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 10, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 17, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,148
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 24, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,198
AmaWaterways – AmaMelodia
Departs Oct 28, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,348
AmaWaterways – AmaMelodia
Departs Nov 04, 2026 from Cartagena, Spain
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,049
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Nov 07, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,348
AmaWaterways – AmaMelodia
Departs Nov 11, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,398
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Nov 14, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,848
AmaWaterways – AmaMelodia
Departs Nov 18, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,598
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Nov 21, 2026 from Cartagena, Spain
Up to 1 deal
25-night south america cruise
$5,237
62% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Nov 24, 2026 from Miami, Florida
Up to 6 deals including an Avoya Exclusive
Secret Rate
7-night south america cruise
$4,998
AmaWaterways – AmaMelodia
Departs Nov 25, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,248
AmaWaterways – AmaMelodia
Departs Dec 02, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,349
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Dec 05, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,149
AmaWaterways – AmaMelodia
Departs Dec 09, 2026 from Barranquilla, Colombia
7-night south america cruise
$4,548
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Dec 12, 2026 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$3,749
AmaWaterways – AmaMelodia
Departs Dec 16, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,999
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Dec 19, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,399
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 02, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,198
AmaWaterways – AmaMelodia
Departs Jan 06, 2027 from Barranquilla, Colombia
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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