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Best South America Cruises

Showing 701-725 of 821 results
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7-night south america cruise
$904
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 22, 2028 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$869
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 26, 2028 from Santos, Brazil
Up to 1 deal
20-night south america cruise
$17,510
Silversea – Silver Ray
5.0 (3)
Departs Feb 29, 2028 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$904
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 01, 2028 from MACEIO
Up to 1 deal
3-night south america cruise
$439
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 03, 2028 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$964
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Mar 03, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$869
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 04, 2028 from Santos, Brazil
Up to 1 deal
4-night south america cruise
$479
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 06, 2028 from Santos, Brazil
Up to 1 deal
3-night south america cruise
$439
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 16, 2028 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$869
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 18, 2028 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$924
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Mar 27, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$4,889
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 04, 2028 from Barranquilla, Colombia
18-night south america cruise
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
33-night south america cruise
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Secret Rate
20-night south america cruise + tour
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 02, 2026 from Rio de Janeiro, Brazil
21-night south america cruise
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 07, 2026 from Buenos Aires, Argentina
21-night south america cruise
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 16, 2026 from Lima (Callao), Peru
Up to 1 deal
22-night south america cruise + tour
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Jan 01, 2027 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
22-night south america cruise + tour
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Jan 18, 2027 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
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AmaWaterways – AmaMelodia
Departs Jun 09, 2027 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
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AmaWaterways – AmaMelodia
Departs Aug 18, 2027 from Barranquilla, Colombia
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
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AmaWaterways – AmaMagdalena
5.0 (1)
Departs Oct 30, 2027 from Barranquilla, Colombia
Up to 1 deal including an Avoya Exclusive
21-night south america cruise
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Nov 30, 2027 from Lima (Callao), Peru
Up to 3 deals including an Avoya Exclusive
22-night south america cruise + tour
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Princess Cruises – Majestic Princess
4.4 (68)
Departs Jan 02, 2028 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
16-night south america cruise
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Holland America – Oosterdam
4.2 (213)
Departs Nov 18, 2026 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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