Menu
Call
No Avoya Fees. Click Here!

Best South America Cruises

Showing 676-700 of 821 results
Meet Natalie Thompson, one of Avoya's trusted travel advisors.
Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.
Choose your adventure and let us handle the rest.
Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.
Help Me Plan
6-night south america cruise
$889
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 02, 2028 from Santos, Brazil
Up to 1 deal
6-night south america cruise
$939
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 05, 2028 from Salvador, Brazil
Up to 1 deal
9-night south america cruise
$1,300
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Jan 07, 2028 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,029
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 08, 2028 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,029
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 15, 2028 from Santos, Brazil
Up to 1 deal
9-night south america cruise
$1,300
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Jan 16, 2028 from Buenos Aires, Argentina
Up to 1 deal
4-night south america cruise
$519
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Jan 23, 2028 from Santos, Brazil
Up to 1 deal
9-night south america cruise
$1,300
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Jan 25, 2028 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,064
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 26, 2028 from MACEIO
Up to 1 deal
9-night south america cruise
$1,247
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Jan 28, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
4-night south america cruise
$519
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Jan 31, 2028 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$954
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 02, 2028 from MACEIO
Up to 1 deal
9-night south america cruise
$1,190
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 03, 2028 from Buenos Aires, Argentina
Up to 1 deal
3-night south america cruise
$409
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 04, 2028 from Santos, Brazil
Up to 1 deal
9-night south america cruise
$1,137
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 06, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
4-night south america cruise
$479
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 07, 2028 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$954
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 08, 2028 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$904
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 09, 2028 from MACEIO
Up to 1 deal
7-night south america cruise
$869
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 12, 2028 from Santos, Brazil
Up to 1 deal
9-night south america cruise
$1,190
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 12, 2028 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$904
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 15, 2028 from Salvador, Brazil
Up to 1 deal
9-night south america cruise
$1,137
48% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 15, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
3-night south america cruise
$439
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 18, 2028 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$869
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 19, 2028 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$929
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 21, 2028 from Buenos Aires, Argentina
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

FAQ's

Don't Miss the Latest Deals!
Talk to a Vacation Planner
Avoya Travel Logo Mark
Why Choose Avoya?
U.S. / Canada:
1-888-447-8459

International: +1-760-305-5070
Avoya Travel.
CST: 2085569-40
Fla. Seller of Travel Ref. No. ST36781
© Avoya Travel®. All Rights Reserved.
Avoya Travel Logo