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Best South America Cruises

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33-night south america cruise
$32,799
50% Off List
Oceania Cruises – Insignia
4.3 (172)
Departs Feb 14, 2027 from Santiago (Valparaiso), Chile
Up to 3 deals
7-night south america cruise
$1,106
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 16, 2027 from Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,106
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 17, 2027 from MACEIO
Up to 3 deals
3-night south america cruise
$659
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 19, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,226
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 23, 2027 from Salvador, Brazil
Up to 3 deals
4-night south america cruise
$609
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 25, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$6,148
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Feb 27, 2027 from Cartagena, Colombia
Up to 2 deals
3-night south america cruise
$599
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 01, 2027 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,353
56% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Mar 10, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
3-night south america cruise
$669
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 11, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,119
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 13, 2027 from Santos, Brazil
Up to 3 deals
8-night south america cruise
$1,985
34% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Mar 15, 2027 from Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,106
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 17, 2027 from MACEIO
Up to 3 deals
7-night south america cruise
$1,096
48% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 23, 2027 from Salvador, Brazil
Up to 3 deals
7-night south america cruise
$1,079
47% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Mar 27, 2027 from Santos, Brazil
Up to 3 deals
1-night south america cruise
$89
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Apr 03, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$864
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 07, 2027 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$864
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 08, 2027 from MACEIO
Up to 1 deal
7-night south america cruise
$864
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 14, 2027 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$864
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 15, 2027 from MACEIO
Up to 1 deal
8-night south america cruise
$1,219
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 18, 2027 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,264
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 21, 2027 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,549
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 26, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,584
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 29, 2027 from Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,641
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 29, 2027 from Rio de Janeiro, Brazil
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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