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Best South America Cruises

Showing 26-50 of 545 results
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7-night south america cruise
$4,598
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 25, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 29, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,348
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 02, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,598
AmaWaterways – AmaMelodia
Departs May 06, 2026 from Cartagena, Spain
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,698
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 09, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,049
AmaWaterways – AmaMelodia
Departs May 13, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,799
AmaWaterways – AmaMelodia
Departs May 20, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 27, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 30, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,149
AmaWaterways – AmaMelodia
Departs Jun 03, 2026 from Cartagena, Spain
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 06, 2026 from Cartagena, Spain
7-night south america cruise
$4,448
AmaWaterways – AmaMelodia
Departs Jun 10, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,748
AmaWaterways – AmaMelodia
Departs Jun 17, 2026 from Cartagena, Spain
Up to 3 deals including Avoya Exclusives
7-night south america cruise
$3,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 20, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,948
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 27, 2026 from Barranquilla, Colombia
7-night south america cruise
$4,198
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jul 04, 2026 from Cartagena, Spain
Up to 2 deals
7-night south america cruise
$3,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jul 11, 2026 from Barranquilla, Colombia
Up to 2 deals
7-night south america cruise
$3,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jul 18, 2026 from Cartagena, Spain
Up to 2 deals
7-night south america cruise
$3,149
AmaWaterways – AmaMelodia
Departs Jul 22, 2026 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$3,649
AmaWaterways – AmaMelodia
Departs Aug 05, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,948
AmaWaterways – AmaMelodia
Departs Aug 12, 2026 from Cartagena, Spain
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$3,149
AmaWaterways – AmaMelodia
Departs Aug 19, 2026 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
7-night south america cruise
$4,448
AmaWaterways – AmaMelodia
Departs Aug 26, 2026 from Cartagena, Spain
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,948
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Aug 29, 2026 from Cartagena, Spain
Up to 2 deals
7-night south america cruise
$3,399
AmaWaterways – AmaMelodia
Departs Sep 02, 2026 from Barranquilla, Colombia
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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