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Best South America Cruises

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4-night south america cruise
$629
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 12, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 13, 2027 from Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$889
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 13, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 14, 2027 from ITAJAI
Up to 2 deals
7-night south america cruise
$889
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 14, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$861
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 15, 2027 from CAMBORIU
Up to 2 deals
3-night south america cruise
$509
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 16, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 16, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,060
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 16, 2027 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,060
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 17, 2027 from MACEIO
Up to 2 deals
7-night south america cruise
$928
48% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 18, 2027 from Buenos Aires, Argentina
Up to 2 deals
3-night south america cruise
$531
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 19, 2027 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,241
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Feb 19, 2027 from Buenos Aires, Argentina
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 20, 2027 from Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$909
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 20, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 21, 2027 from ITAJAI
Up to 2 deals
7-night south america cruise
$1,061
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 21, 2027 from Santos, Brazil
Up to 2 deals
4-night south america cruise
$629
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 22, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$841
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 22, 2027 from CAMBORIU
Up to 2 deals
7-night south america cruise
$831
50% Off List
MSC Cruises – MSC Lirica
4.3 (6)
Departs Feb 23, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
7-night south america cruise
$1,060
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 23, 2027 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,060
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Feb 24, 2027 from MACEIO
Up to 2 deals
7-night south america cruise
$928
48% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 25, 2027 from Buenos Aires, Argentina
Up to 2 deals
17-night south america cruise
$9,799
Viking Ocean Cruises – Viking Jupiter
4.6 (28)
Departs Feb 25, 2027 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
3-night south america cruise
$814
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 26, 2027 from Santos, Brazil
Up to 2 deals

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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