Menu
Call
No Avoya Fees on Cruises or Tours. Click Here!

Best South America Cruises

Showing 276-300 of 491 results
Meet Natalie Thompson, one of Avoya's trusted travel advisors.
Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.
Choose your adventure and let us handle the rest.
Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.
Help Me Plan
4-night south america cruise
$475
58% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 13, 2026 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$453
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 15, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$970
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 15, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,012
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 16, 2026 from MACEIO
Up to 2 deals
3-night south america cruise
$435
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 17, 2026 from Santos, Brazil
Up to 2 deals
11-night south america cruise + tour
$17,848
Seabourn – Seabourn Venture
5.0 (2)
Departs Dec 18, 2026 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
8-night south america cruise
$1,089
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 2 deals
7-night south america cruise
$1,159
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 19, 2026 from Santos, Brazil
Up to 2 deals
17-night south america cruise
$9,299
Viking Ocean Cruises – Viking Jupiter
4.6 (28)
Departs Dec 19, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
8-night south america cruise
$1,392
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
5-night south america cruise
$894
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 21, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,360
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 22, 2026 from Salvador, Brazil
Up to 2 deals
3-night south america cruise
$369
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 23, 2026 from MACEIO
3-night south america cruise
$419
49% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Dec 26, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,619
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 26, 2026 from Santos, Brazil
Up to 2 deals
9-night south america cruise
$1,895
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 27, 2026 from Buenos Aires, Argentina
Up to 2 deals
9-night south america cruise
$2,365
49% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 28, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,594
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 29, 2026 from Salvador, Brazil
Up to 2 deals
3-night south america cruise
$549
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Jan 02, 2027 from Santos, Brazil
Up to 2 deals
4-night south america cruise
$579
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 02, 2027 from Santos, Brazil
7-night south america cruise
$1,059
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 02, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,264
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Jan 05, 2027 from Salvador, Brazil
Up to 2 deals
9-night south america cruise
$1,466
49% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Jan 05, 2027 from Buenos Aires, Argentina
Up to 2 deals
34-night south america cruise
$5,369
Cunard – Queen Anne
5.0 (1)
Departs Jan 05, 2027 from Hamburg, Germany
Up to 2 deals including an Avoya Exclusive
17-night south america cruise
$9,999
Viking Ocean Cruises – Viking Jupiter
4.6 (28)
Departs Jan 05, 2027 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

FAQ's

Don't Miss the Latest Deals!
Talk to a Vacation Planner
Avoya Travel Logo Mark
Why Choose Avoya?
U.S. / Canada: 1-888-877-7042
UK: 0-800-098-8475
Australia: 1-800-651-320
International: 001-760-305-5070
Avoya Travel. Beyond The Web.®
CST: 2085569-40
Fla. Seller of Travel Ref. No. ST36781
© Avoya Travel®. All Rights Reserved.
Avoya Travel Logo