Menu
Call
No Avoya Fees on Cruises or Tours. Click Here!

Best South America Cruises

Showing 251-275 of 491 results
Meet Natalie Thompson, one of Avoya's trusted travel advisors.
Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.
Choose your adventure and let us handle the rest.
Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.
Help Me Plan
7-night south america cruise
$1,049
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 31, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,468
MSC Cruises – MSC Seaview
4.6 (5)
Departs Apr 01, 2026 from MACEIO
Up to 2 deals
7-night south america cruise
$1,024
MSC Cruises – MSC Seaview
4.6 (5)
Departs Apr 04, 2026 from Santos, Brazil
Up to 2 deals
16-night south america cruise
$8,414
Seabourn – Seabourn Venture
5.0 (2)
Departs Oct 13, 2026 from Bridgetown, Barbados
Up to 1 deal including an Avoya Exclusive
Secret Rate
12-night south america cruise
$10,995
Viking Ocean Cruises – Viking Polaris
5.0 (1)
Departs Nov 13, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
4-night south america cruise
$475
58% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Nov 16, 2026 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$423
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Nov 20, 2026 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$459
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Nov 23, 2026 from Santos, Brazil
Up to 2 deals
12-night south america cruise
$9,995
Viking Ocean Cruises – Viking Octantis
4.7 (9)
Departs Nov 23, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
4-night south america cruise
$569
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Nov 26, 2026 from Santos, Brazil
Up to 2 deals
4-night south america cruise
$585
50% Off List
MSC Cruises – MSC Divina
3.8 (92)
Departs Nov 29, 2026 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$363
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Nov 30, 2026 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$509
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 02, 2026 from Santos, Brazil
Up to 2 deals
17-night south america cruise
$8,999
Viking Ocean Cruises – Viking Jupiter
4.6 (28)
Departs Dec 02, 2026 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
3-night south america cruise
$383
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 03, 2026 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,142
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 03, 2026 from Buenos Aires, Argentina
Up to 2 deals
3-night south america cruise
$521
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 05, 2026 from Santos, Brazil
4-night south america cruise
$569
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 05, 2026 from Santos, Brazil
7-night south america cruise
$1,037
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 05, 2026 from Santos, Brazil
Up to 2 deals
4-night south america cruise
$475
58% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 06, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,012
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 08, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$981
50% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 09, 2026 from MACEIO
Up to 2 deals
3-night south america cruise
$447
50% Off List
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 10, 2026 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$1,142
50% Off List
MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 11, 2026 from Buenos Aires, Argentina
Up to 2 deals
7-night south america cruise
$849
49% Off List
MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 12, 2026 from Santos, Brazil
Up to 2 deals

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

FAQ's

Don't Miss the Latest Deals!
Talk to a Vacation Planner
Avoya Travel Logo Mark
Why Choose Avoya?
U.S. / Canada: 1-888-877-7042
UK: 0-800-098-8475
Australia: 1-800-651-320
International: 001-760-305-5070
Avoya Travel. Beyond The Web.®
CST: 2085569-40
Fla. Seller of Travel Ref. No. ST36781
© Avoya Travel®. All Rights Reserved.
Avoya Travel Logo