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Best South America Cruises

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9-night south america cruise
$2,043
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Mar 06, 2026 from Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,107
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 07, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,427
MSC Cruises – MSC Armonia
3.2 (19)
Departs Mar 07, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
7-night south america cruise
$1,060
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 08, 2026 from Santos, Brazil
Up to 3 deals
3-night south america cruise
$754
47% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Mar 10, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,049
52% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 10, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,061
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 11, 2026 from MACEIO
Up to 2 deals
7-night south america cruise
$1,251
24% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 12, 2026 from Buenos Aires, Argentina
Up to 3 deals
4-night south america cruise
$803
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Mar 13, 2026 from Santos, Brazil
Up to 2 deals
1-night south america cruise
$89
MSC Cruises – MSC Armonia
3.2 (19)
Departs Mar 14, 2026 from Rio de Janeiro, Brazil
7-night south america cruise
$1,107
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 14, 2026 from Santos, Brazil
Up to 2 deals
8-night south america cruise
$2,494
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Mar 14, 2026 from Montevideo, Uruguay
Up to 3 deals
13-night south america cruise
$10,295
2% Off List
Viking Ocean Cruises – Viking Octantis
4.7 (9)
Departs Mar 14, 2026 from Ushuaia, Argentina
7-night south america cruise
$1,040
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 15, 2026 from Santos, Brazil
Up to 3 deals
8-night south america cruise
$2,370
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Mar 15, 2026 from Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,147
47% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 17, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,049
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 18, 2026 from MACEIO
Up to 2 deals
7-night south america cruise
$1,431
29% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 19, 2026 from Buenos Aires, Argentina
Up to 3 deals
7-night south america cruise
$1,120
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 21, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,261
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 22, 2026 from Santos, Brazil
Up to 3 deals
7-night south america cruise
$1,067
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 24, 2026 from Salvador, Brazil
Up to 2 deals
7-night south america cruise
$1,505
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 25, 2026 from MACEIO
Up to 2 deals
19-night south america cruise
$13,995
18% Off List
Viking Ocean Cruises – Viking Octantis
4.7 (9)
Departs Mar 26, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$773
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 28, 2026 from Santos, Brazil
Up to 2 deals
4-night south america cruise
$917
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 29, 2026 from Santos, Brazil
Up to 3 deals

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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