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Best South America Cruises

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21-night south america cruise
$7,899
Oceania Cruises – Insignia
4.3 (172)
Departs Jan 03, 2027 from Lima (Callao), Peru
Up to 5 deals including Avoya Exclusives
15-night south america cruise
$2,402
Princess Cruises – Majestic Princess
4.4 (68)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
21-night south america cruise
$7,949
50% Off List
Oceania Cruises – Insignia
4.3 (172)
Departs Feb 14, 2027 from Santiago (Valparaiso), Chile
Up to 4 deals including an Avoya Exclusive
Secret Rate
21-night south america cruise
$9,779
Azamara Cruises – Azamara Journey
4.6 (159)
Departs Feb 17, 2027 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
21-night south america cruise
$6,699
50% Off List
Oceania Cruises – Insignia
4.3 (172)
Departs Mar 19, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
17-night south america cruise
$4,029
Azamara Cruises – Azamara Quest
4.6 (127)
Departs May 24, 2027 from San Diego, California
Up to 1 deal including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
9-night south america cruise
$2,969
Azamara Cruises – Azamara Quest
4.6 (127)
Departs Jan 05, 2028 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
17-night south america cruise
$3,400
Princess Cruises – Majestic Princess
4.4 (68)
Departs Jan 07, 2028 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
10-night south america cruise
$3,829
Azamara Cruises – Azamara Quest
4.6 (127)
Departs Jan 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 3 deals including Avoya Exclusives
Avoya Exclusive Rate
25-night south america cruise
$18,099
50% Off List
Oceania Cruises – Insignia
4.3 (172)
Departs Nov 24, 2026 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
15-night south america cruise
$4,399
Oceania Cruises – Insignia
4.3 (172)
Departs Dec 19, 2026 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$3,498
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 02, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
18-night south america cruise
$18,899
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 04, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
14-night south america cruise
$4,726
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 16, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
14-night south america cruise
$5,092
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 30, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
18-night south america cruise
$13,999
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 02, 2027 from Buenos Aires, Argentina
Up to 4 deals including Avoya Exclusives
Secret Rate
14-night south america cruise
$3,114
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 13, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
18-night south america cruise
$15,199
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 20, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
Secret Rate
14-night south america cruise
$3,262
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 27, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
19-night south america cruise + tour
$4,848
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Dec 15, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
16-night south america cruise
$4,059
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Dec 17, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
19-night south america cruise + tour
$3,868
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Dec 30, 2027 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
14-night south america cruise
$4,249
Azamara Cruises – Azamara Quest
4.6 (127)
Departs Feb 28, 2028 from Rio de Janeiro, Brazil
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
14-night south america cruise
$1,942
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 05, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
14-night south america cruise
$2,223
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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