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Best Panama Canal Cruises

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33-night panama canal cruise
$3,209
43% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 08, 2026 from Marseille, France
Up to 3 deals
7-night panama canal cruise
$3,357
Windstar Cruises – Star Pride
4.5 (95)
Departs Dec 06, 2027 from Colon, Panama
7-night panama canal cruise
$3,357
Windstar Cruises – Star Pride
4.5 (95)
Departs Dec 13, 2027 from Puerto Caldera (Puntarenas), Costa Rica
7-night panama canal cruise
$3,757
Windstar Cruises – Star Pride
4.5 (95)
Departs Dec 20, 2027 from Colon, Panama
7-night panama canal cruise
$3,757
Windstar Cruises – Star Pride
4.5 (95)
Departs Dec 27, 2027 from Puerto Caldera (Puntarenas), Costa Rica
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 03, 2028 from Colon, Panama
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 10, 2028 from Puerto Caldera (Puntarenas), Costa Rica
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 17, 2028 from Colon, Panama
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 24, 2028 from Puerto Caldera (Puntarenas), Costa Rica
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 31, 2028 from Colon, Panama
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 07, 2028 from Puerto Caldera (Puntarenas), Costa Rica
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 14, 2028 from Colon, Panama
7-night panama canal cruise
$2,361
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 21, 2028 from Puerto Caldera (Puntarenas), Costa Rica
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Feb 09, 2026 from Los Angeles, California
Up to 4 deals including an Avoya Exclusive
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Feb 25, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Jan 14, 2028 from Fort Lauderdale, Florida
Up to 2 deals
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Jan 30, 2028 from Los Angeles, California
Up to 2 deals
12-night panama canal cruise
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Princess Cruises – Caribbean Princess
4.1 (256)
Departs Feb 12, 2028 from Fort Lauderdale, Florida
Up to 2 deals
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Feb 15, 2028 from Fort Lauderdale, Florida
Up to 2 deals
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Mar 18, 2028 from Fort Lauderdale, Florida
Up to 2 deals
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Apr 03, 2028 from Los Angeles, California
Up to 2 deals
16-night panama canal cruise
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Princess Cruises – Emerald Princess
4.2 (199)
Departs Apr 22, 2028 from Fort Lauderdale, Florida
Up to 2 deals
15-night panama canal cruise
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Holland America – Zuiderdam
4.3 (156)
Departs Feb 27, 2026 from San Diego, California
Up to 2 deals including Avoya Exclusives
15-night panama canal cruise
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Holland America – Eurodam
4.3 (283)
Departs Apr 05, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
27-night panama canal cruise
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Holland America – Zuiderdam
4.3 (156)
Departs Feb 15, 2026 from San Diego, California
Up to 1 deal including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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