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Best Panama Canal Cruises

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21-night panama canal cruise
$3,434
Holland America – Oosterdam
4.2 (212)
Departs Apr 07, 2028 from Fort Lauderdale, Florida
21-night panama canal cruise
$1,580
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives
18-night panama canal cruise
$1,744
55% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 08, 2027 from Miami, Florida
Up to 2 deals
19-night panama canal cruise
$8,998
Seabourn – Seabourn Quest
4.6 (43)
Departs May 11, 2027 from Long Beach, California
Up to 3 deals including an Avoya Exclusive
Secret Rate
18-night panama canal cruise
$1,877
48% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 06, 2028 from Miami, Florida
Up to 3 deals
15-night panama canal cruise
$2,779
Holland America – Oosterdam
4.2 (212)
Departs Apr 07, 2028 from Fort Lauderdale, Florida
28-night panama canal cruise
$2,513
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
40-night panama canal cruise
$3,669
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
33-night panama canal cruise
$2,967
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$819
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Oct 08, 2026 from Seattle, Washington
Up to 6 deals
26-night panama canal cruise
$3,049
Cunard – Queen Victoria
4.4 (19)
Departs Jan 10, 2027 from Southampton, United Kingdom
Up to 2 deals including an Avoya Exclusive
17-night panama canal cruise
$2,599
Cunard – Queen Victoria
4.4 (19)
Departs Jan 19, 2027 from New York City, New York
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$1,029
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Mar 29, 2027 from Mobile, Alabama
Up to 3 deals
16-night panama canal cruise
$1,169
Carnival Cruises – Carnival Legend
4.3 (51)
Departs Apr 04, 2027 from Tampa, Florida
Up to 3 deals
14-night panama canal cruise
$1,289
Carnival Cruises – Carnival Valor
4.5 (71)
Departs Sep 26, 2027 from Mobile, Alabama
Up to 2 deals
29-night panama canal cruise
$5,769
Cunard – Queen Anne
5.0 (1)
Departs Jan 09, 2028 from Hamburg, Germany
27-night panama canal cruise
$4,919
Cunard – Queen Anne
5.0 (1)
Departs Jan 11, 2028 from Southampton, United Kingdom
14-night panama canal cruise
$3,119
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 13, 2028 from Los Angeles, California
23-night panama canal cruise
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Princess Cruises – Star Princess
Departs Sep 27, 2026 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
Secret Rate
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Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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