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Best Panama Canal Cruises

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14-night panama canal cruise
$1,689
Cunard – Queen Anne
5.0 (1)
Departs Apr 05, 2026 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
35-night panama canal cruise
$2,819
51% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 06, 2026 from Rome (Civitavecchia), Italy
Up to 3 deals
34-night panama canal cruise
$3,589
46% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 07, 2026 from Genoa, Italy
Up to 3 deals
32-night panama canal cruise
$3,629
45% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 09, 2026 from Barcelona, Spain
Up to 3 deals
30-night panama canal cruise
$2,000
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 14, 2026 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
18-night panama canal cruise
$1,549
57% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 23, 2026 from Miami, Florida
Up to 2 deals
28-night panama canal cruise
$2,499
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
40-night panama canal cruise
$3,430
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
33-night panama canal cruise
$3,299
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
19-night panama canal cruise
$1,832
49% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Sep 28, 2026 from Seattle, Washington, United States
Up to 3 deals
26-night panama canal cruise
$2,899
Cunard – Queen Victoria
4.4 (19)
Departs Jan 10, 2027 from Southampton, United Kingdom
Up to 2 deals including an Avoya Exclusive
17-night panama canal cruise
$2,609
Cunard – Queen Victoria
4.4 (19)
Departs Jan 19, 2027 from New York City, New York
Up to 2 deals including an Avoya Exclusive
18-night panama canal cruise
$1,817
48% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 08, 2027 from Miami, Florida
Up to 2 deals
29-night panama canal cruise
$6,329
Cunard – Queen Anne
5.0 (1)
Departs Jan 09, 2028 from Hamburg, Germany
Up to 1 deal including an Avoya Exclusive
27-night panama canal cruise
$5,389
Cunard – Queen Anne
5.0 (1)
Departs Jan 11, 2028 from Southampton, United Kingdom
Up to 1 deal including an Avoya Exclusive
16-night panama canal cruise
$1,224
Carnival Cruises – Carnival Miracle
4.3 (63)
Departs Apr 11, 2026 from Tampa, Florida
Up to 4 deals
16-night panama canal cruise
$1,059
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Apr 12, 2026 from Mobile, Alabama
Up to 4 deals
16-night panama canal cruise
$1,054
Carnival Cruises – Carnival Miracle
4.3 (63)
Departs Sep 26, 2026 from Seattle, Washington
Up to 4 deals
16-night panama canal cruise
$1,104
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Oct 08, 2026 from Seattle, Washington
Up to 4 deals
19-night panama canal cruise
$7,649
Seabourn – Seabourn Quest
4.6 (43)
Departs May 11, 2027 from Long Beach, California
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$3,129
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 13, 2028 from Los Angeles, California
Up to 1 deal including an Avoya Exclusive
16-night panama canal cruise
$1,049
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Mar 29, 2027 from Mobile, Alabama
Up to 2 deals
16-night panama canal cruise
$1,474
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Sep 25, 2027 from Seattle, Washington
Up to 1 deal
14-night panama canal cruise
$1,224
Carnival Cruises – Carnival Valor
4.5 (71)
Departs Sep 26, 2027 from Mobile, Alabama
Up to 1 deal
7-night panama canal cruise
$3,236
Windstar Cruises – Star Pride
4.5 (95)
Departs Mar 02, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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