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Best Panama Canal Cruises

Showing 151-171 of 171 results
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27-night panama canal cruise
$5,669
Cunard – Queen Anne
5.0 (1)
Departs Jan 11, 2028 from Southampton, United Kingdom
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$2,479
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 13, 2028 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
11-night panama canal cruise
$137,499
51% Off List
Regent Cruises – Seven Seas Prestige
Departs Feb 22, 2027 from Panama City (Fuerte Amador), Panama
Up to 3 deals including an Avoya Exclusive
23-night panama canal cruise
$1,986
Princess Cruises – Island Princess
4.2 (157)
Departs Apr 19, 2027 from Fort Lauderdale, Florida
Up to 1 deal
23-night panama canal cruise
$2,991
Princess Cruises – Island Princess
4.2 (157)
Departs Oct 06, 2027 from Vancouver, BC, Canada
Up to 2 deals including an Avoya Exclusive
21-night panama canal cruise
$2,458
Princess Cruises – Island Princess
4.2 (157)
Departs Apr 19, 2028 from Fort Lauderdale, Florida
Up to 1 deal
20-night panama canal cruise
$2,028
Princess Cruises – Emerald Princess
4.2 (199)
Departs Apr 22, 2028 from Fort Lauderdale, Florida
Up to 1 deal
17-night panama canal cruise
$8,399
50% Off List
Oceania Cruises – Sonata
Departs Nov 16, 2028 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$7,899
50% Off List
Oceania Cruises – Sonata
Departs Dec 03, 2028 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
11-night panama canal cruise
$7,999
64% Off List
Regent Cruises – Seven Seas Prestige
Departs Dec 09, 2028 from Miami, Florida
Up to 2 deals
14-night panama canal cruise
$9,999
63% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Dec 13, 2028 from Miami, Florida
Up to 2 deals
12-night panama canal cruise
$4,999
50% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Jan 07, 2029 from Miami, Florida
12-night panama canal cruise
$4,999
50% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Jan 19, 2029 from Panama City (Fuerte Amador), Panama
12-night panama canal cruise
$6,399
50% Off List
Oceania Cruises – Sonata
Departs Jan 30, 2029 from Miami, Florida
16-night panama canal cruise
$11,899
61% Off List
Regent Cruises – Seven Seas Prestige
Departs Feb 07, 2029 from Miami, Florida
Up to 2 deals
11-night panama canal cruise
$5,699
50% Off List
Oceania Cruises – Sonata
Departs Feb 11, 2029 from Panama City (Fuerte Amador), Panama
14-night panama canal cruise
$10,199
63% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Feb 26, 2029 from Miami, Florida
Up to 2 deals
16-night panama canal cruise
$11,799
61% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 05, 2029 from Los Angeles, California
Up to 2 deals
28-night panama canal cruise
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Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 3 deals including an Avoya Exclusive
40-night panama canal cruise
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Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 3 deals including an Avoya Exclusive
33-night panama canal cruise
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Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 3 deals including an Avoya Exclusive
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Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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