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Best Panama Canal Cruises

Showing 151-175 of 179 results
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18-night panama canal cruise
$1,817
48% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 06, 2028 from Miami, Florida
Up to 3 deals
16-night panama canal cruise
$2,064
Virgin Voyages – Brilliant Lady
Departs Mar 26, 2027 from Miami, Florida
Up to 1 deal
17-night panama canal cruise
$1,853
Virgin Voyages – Brilliant Lady
Departs Nov 27, 2027 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$2,064
Virgin Voyages – Brilliant Lady
Departs Feb 21, 2028 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
26-night panama canal cruise
$2,589
Cunard – Queen Victoria
4.4 (19)
Departs Jan 10, 2027 from Southampton, United Kingdom
Up to 2 deals including an Avoya Exclusive
17-night panama canal cruise
$2,559
Cunard – Queen Victoria
4.4 (19)
Departs Jan 19, 2027 from New York City, New York
Up to 3 deals including Avoya Exclusives
16-night panama canal cruise
$911
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Mar 29, 2027 from Mobile, Alabama
Up to 7 deals
16-night panama canal cruise
$1,061
Carnival Cruises – Carnival Legend
4.3 (51)
Departs Apr 04, 2027 from Tampa, Florida
Up to 7 deals
14-night panama canal cruise
$1,172
Carnival Cruises – Carnival Valor
4.5 (71)
Departs Sep 26, 2027 from Mobile, Alabama
Up to 6 deals
29-night panama canal cruise
$6,069
Cunard – Queen Anne
5.0 (1)
Departs Jan 09, 2028 from Hamburg, Germany
Up to 2 deals including an Avoya Exclusive
27-night panama canal cruise
$5,129
Cunard – Queen Anne
5.0 (1)
Departs Jan 11, 2028 from Southampton, United Kingdom
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$2,899
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 13, 2028 from Los Angeles, California
Up to 3 deals including Avoya Exclusives
16-night panama canal cruise
$1,221
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Apr 16, 2028 from Tampa, Florida
Up to 2 deals
15-night panama canal cruise
$3,899
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 21, 2029 from Los Angeles, California
11-night panama canal cruise
$1,995
Celebrity Cruises – Celebrity Beyond
4.4 (90)
Departs Jan 15, 2029 from Fort Lauderdale, Florida
11-night panama canal cruise
$2,013
Celebrity Cruises – Celebrity Beyond
4.4 (90)
Departs Feb 12, 2029 from Fort Lauderdale, Florida
11-night panama canal cruise
$2,008
Celebrity Cruises – Celebrity Beyond
4.4 (90)
Departs Mar 12, 2029 from Fort Lauderdale, Florida
11-night panama canal cruise
$1,995
Celebrity Cruises – Celebrity Beyond
4.4 (90)
Departs Mar 26, 2029 from Fort Lauderdale, Florida
15-night panama canal cruise
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Holland America – Zuiderdam
4.3 (157)
Departs Jan 30, 2027 from San Diego, California
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
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Princess Cruises – Crown Princess
4.3 (211)
Departs Dec 03, 2026 from Los Angeles, California
Up to 4 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Dec 12, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
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Princess Cruises – Caribbean Princess
4.1 (257)
Departs Dec 17, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
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Princess Cruises – Island Princess
4.2 (157)
Departs Dec 28, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
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Princess Cruises – Caribbean Princess
4.1 (257)
Departs Jan 10, 2027 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
15-night panama canal cruise
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Royal Caribbean – Serenade of the Seas
4.5 (214)
Departs Oct 07, 2027 from San Diego, California
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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