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Best Panama Canal Cruises

Showing 126-150 of 194 results
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16-night panama canal cruise
$1,899
Holland America – Eurodam
4.3 (283)
Departs Oct 08, 2026 from San Diego, California
Up to 3 deals including an Avoya Exclusive
20-night panama canal cruise
$2,204
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
21-night panama canal cruise
$2,049
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Apr 11, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
21-night panama canal cruise
$3,039
Holland America – Eurodam
4.3 (283)
Departs Oct 02, 2027 from Seattle, Washington
Up to 2 deals including an Avoya Exclusive
20-night panama canal cruise
$2,949
Holland America – Eurodam
4.3 (283)
Departs Oct 03, 2027 from Vancouver, BC, Canada
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$2,769
Holland America – Eurodam
4.3 (283)
Departs Oct 07, 2027 from San Diego, California
Up to 2 deals including an Avoya Exclusive
32-night panama canal cruise
$15,399
50% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Oct 10, 2027 from Montreal, Quebec, Canada
Up to 4 deals including an Avoya Exclusive
15-night panama canal cruise
$2,674
Holland America – Zaandam
4.5 (132)
Departs Dec 18, 2027 from San Diego, California
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$7,999
Oceania Cruises – Sonata
Departs Dec 19, 2027 from Miami, Florida
Up to 1 deal
11-night panama canal cruise
$2,013
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Jan 03, 2028 from Fort Lauderdale, Florida
Up to 4 deals
16-night panama canal cruise
$7,899
Oceania Cruises – Sonata
Departs Jan 06, 2028 from Los Angeles, California
Up to 1 deal
11-night panama canal cruise
$2,137
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Feb 14, 2028 from Fort Lauderdale, Florida
Up to 4 deals
11-night panama canal cruise
$2,154
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Mar 27, 2028 from Fort Lauderdale, Florida
Up to 4 deals
16-night panama canal cruise
$2,864
Holland America – Eurodam
4.3 (283)
Departs Apr 01, 2028 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
22-night panama canal cruise
$3,409
Holland America – Eurodam
4.3 (283)
Departs Apr 01, 2028 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
19-night panama canal cruise
$1,114
66% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Sep 28, 2026 from Seattle, Washington
Up to 4 deals including an Avoya Exclusive
8-night panama canal cruise
$2,886
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,065
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 12, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$5,559
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$2,855
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 19, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
8-night panama canal cruise
$2,662
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 20, 2026 from Balboa, Panama
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$4,080
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 26, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
8-night panama canal cruise
$3,158
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 28, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,555
Windstar Cruises – Wind Star
4.6 (89)
Departs Jan 02, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$2,668
Windstar Cruises – Star Legend
4.5 (86)
Departs Jan 05, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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