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Best Panama Canal Cruises

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25-night panama canal cruise
$16,299
61% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Dec 19, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
16-night panama canal cruise
$10,099
63% Off List
Regent Cruises – Seven Seas Splendor
4.3 (31)
Departs Dec 20, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
14-night panama canal cruise
$8,999
64% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Dec 22, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
11-night panama canal cruise
$2,013
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Jan 03, 2028 from Fort Lauderdale, Florida
Up to 4 deals
15-night panama canal cruise
$2,219
Norwegian Cruise Line – Norwegian Encore
4.4 (76)
Departs Jan 09, 2028 from Los Angeles, California
Up to 1 deal
14-night panama canal cruise
$12,799
61% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Jan 13, 2028 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
15-night panama canal cruise
$2,139
Norwegian Cruise Line – Norwegian Encore
4.4 (76)
Departs Jan 24, 2028 from Miami, Florida
Up to 1 deal
12-night panama canal cruise
$8,799
63% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 02, 2028 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
12-night panama canal cruise
$8,599
63% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
26-night panama canal cruise
$17,049
64% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
19-night panama canal cruise
$2,429
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Apr 14, 2028 from New York City, New York
Up to 1 deal
22-night panama canal cruise
$2,539
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Apr 14, 2028 from New York City, New York
Up to 1 deal
15-night panama canal cruise
$1,809
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 17, 2028 from Miami, Florida
Up to 2 deals
20-night panama canal cruise
$2,399
Holland America – Eurodam
4.3 (283)
Departs Apr 05, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
8-night panama canal cruise
$3,784
Windstar Cruises – Star Seeker
Departs Apr 20, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$5,743
Windstar Cruises – Star Seeker
Departs Apr 20, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
10-night panama canal cruise
$757
Royal Caribbean – Serenade of the Seas
4.5 (214)
Departs Apr 25, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
15-night panama canal cruise
$1,409
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 25, 2026 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
16-night panama canal cruise
$1,729
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Oct 02, 2026 from San Diego, California
Up to 3 deals including Avoya Exclusives
21-night panama canal cruise
$2,299
Holland America – Eurodam
4.3 (283)
Departs Oct 03, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives
8-night panama canal cruise
$3,665
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$4,069
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 12, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$5,927
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
15-night panama canal cruise
$1,999
Holland America – Zaandam
4.5 (132)
Departs Dec 19, 2026 from San Diego, California
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$4,169
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 19, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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