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Best Panama Canal Cruises

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12-night panama canal cruise
$1,400
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 23, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,649
Princess Cruises – Island Princess
4.2 (157)
Departs Dec 29, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
14-night panama canal cruise
$12,299
61% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Jan 13, 2028 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,700
Princess Cruises – Island Princess
4.2 (157)
Departs Mar 02, 2028 from Los Angeles, California
Up to 2 deals
12-night panama canal cruise
$8,799
63% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 02, 2028 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$8,599
63% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 3 deals including an Avoya Exclusive
26-night panama canal cruise
$16,699
64% Off List
Regent Cruises – Seven Seas Prestige
Departs Mar 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$1,550
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Mar 25, 2028 from Fort Lauderdale, Florida
Up to 2 deals
16-night panama canal cruise
$2,000
Princess Cruises – Star Princess
Departs Apr 07, 2028 from Port Canaveral, Florida
Up to 2 deals
15-night panama canal cruise
$1,809
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 17, 2028 from Miami, Florida
16-night panama canal cruise
$1,700
Princess Cruises – Island Princess
4.2 (157)
Departs Apr 19, 2028 from Fort Lauderdale, Florida
Up to 2 deals
11-night panama canal cruise
$1,469
Norwegian Cruise Line – Norwegian Jewel
4.4 (174)
Departs Mar 04, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
11-night panama canal cruise
$1,369
Norwegian Cruise Line – Norwegian Jewel
4.4 (174)
Departs Mar 15, 2026 from Miami, Florida
Up to 9 deals including an Avoya Exclusive
15-night panama canal cruise
$2,054
Holland America – Eurodam
4.3 (283)
Departs Apr 05, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
20-night panama canal cruise
$2,399
Holland America – Eurodam
4.3 (283)
Departs Apr 05, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
17-night panama canal cruise
$1,699
Holland America – Koningsdam
4.2 (239)
Departs Apr 10, 2026 from Fort Lauderdale, Florida
Up to 2 deals including Avoya Exclusives
16-night panama canal cruise
$1,719
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Oct 02, 2026 from San Diego, California
Up to 3 deals including Avoya Exclusives
21-night panama canal cruise
$2,334
Holland America – Eurodam
4.3 (283)
Departs Oct 03, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives
15-night panama canal cruise
$2,324
Holland America – Zaandam
4.5 (132)
Departs Dec 19, 2026 from San Diego, California
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$1,989
Holland America – Zuiderdam
4.3 (156)
Departs Jan 02, 2027 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
15-night panama canal cruise
$2,324
Holland America – Zuiderdam
4.3 (156)
Departs Jan 30, 2027 from San Diego, California
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$2,189
Holland America – Zaandam
4.5 (132)
Departs Mar 14, 2027 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$1,804
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
21-night panama canal cruise
$2,534
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
17-night panama canal cruise
$2,194
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Apr 11, 2027 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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