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Best Panama Canal Cruises

Showing 76-100 of 229 results
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12-night panama canal cruise
$1,182
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 29, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$12,649
59% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Dec 29, 2026 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
14-night panama canal cruise
$13,699
59% Off List
Regent Cruises – Seven Seas Splendor
4.3 (31)
Departs Jan 12, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
16-night panama canal cruise
$1,749
Princess Cruises – Island Princess
4.2 (157)
Departs Jan 29, 2027 from San Diego, California
Up to 7 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$8,749
63% Off List
Regent Cruises – Seven Seas Prestige
Departs Feb 22, 2027 from Panama City (Fuerte Amador), Panama
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,449
Princess Cruises – Crown Princess
4.3 (211)
Departs Apr 04, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
19-night panama canal cruise
$2,539
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Apr 09, 2027 from New York City, New York
Up to 7 deals including an Avoya Exclusive
22-night panama canal cruise
$2,659
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Apr 09, 2027 from New York City, New York
Up to 7 deals including an Avoya Exclusive
18-night panama canal cruise
$3,872
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Sep 18, 2027 from Los Angeles, California
Up to 4 deals
23-night panama canal cruise
$2,532
Princess Cruises – Coral Princess
4.4 (126)
Departs Sep 22, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
18-night panama canal cruise
$1,894
Princess Cruises – Coral Princess
4.4 (126)
Departs Sep 27, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
17-night panama canal cruise
$2,239
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Sep 30, 2027 from Los Angeles, California
Up to 1 deal
23-night panama canal cruise
$2,924
Princess Cruises – Star Princess
Departs Oct 03, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
20-night panama canal cruise
$1,952
Princess Cruises – Island Princess
4.2 (157)
Departs Oct 09, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,950
Princess Cruises – Star Princess
Departs Oct 10, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,449
Princess Cruises – Island Princess
4.2 (157)
Departs Oct 13, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
17-night panama canal cruise
$2,359
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 19, 2027 from Los Angeles, California
Up to 1 deal
20-night panama canal cruise
$2,419
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 19, 2027 from Los Angeles, California
Up to 1 deal
16-night panama canal cruise
$1,549
Princess Cruises – Emerald Princess
4.2 (199)
Departs Oct 24, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$1,249
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 11, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
11-night panama canal cruise
$1,499
Norwegian Cruise Line – Norwegian Jewel
4.4 (174)
Departs Dec 09, 2027 from Miami, Florida
Up to 1 deal
16-night panama canal cruise
$1,449
Princess Cruises – Island Princess
4.2 (157)
Departs Dec 13, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
25-night panama canal cruise
$16,599
61% Off List
Regent Cruises – Seven Seas Voyager
4.5 (82)
Departs Dec 19, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$10,199
63% Off List
Regent Cruises – Seven Seas Splendor
4.3 (31)
Departs Dec 20, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
14-night panama canal cruise
$9,399
64% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Dec 22, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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