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Best Panama Canal Cruises

Showing 76-100 of 194 results
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16-night panama canal cruise
$1,674
Princess Cruises – Island Princess
4.2 (157)
Departs Sep 20, 2026 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
21-night panama canal cruise
$2,299
Holland America – Eurodam
4.3 (283)
Departs Oct 03, 2026 from Seattle, Washington
Up to 4 deals including Avoya Exclusives
16-night panama canal cruise
$1,555
Princess Cruises – Sapphire Princess
4.3 (86)
Departs Nov 06, 2026 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
12-night panama canal cruise
$904
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 11, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
15-night panama canal cruise
$1,899
Holland America – Zaandam
4.5 (132)
Departs Dec 19, 2026 from San Diego, California
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$1,150
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 29, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
16-night panama canal cruise
$13,349
58% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Dec 29, 2026 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
14-night panama canal cruise
$1,599
Holland America – Zuiderdam
4.3 (156)
Departs Jan 02, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,687
Princess Cruises – Island Princess
4.2 (157)
Departs Jan 29, 2027 from San Diego, California
Up to 6 deals including an Avoya Exclusive
Secret Rate
15-night panama canal cruise
$1,799
Holland America – Zuiderdam
4.3 (156)
Departs Jan 30, 2027 from San Diego, California
Up to 3 deals including an Avoya Exclusive
19-night panama canal cruise
$2,968
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Feb 11, 2027 from San Diego, California
Up to 2 deals
16-night panama canal cruise
$2,039
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Feb 13, 2027 from San Diego, California
Up to 2 deals
11-night panama canal cruise
$2,272
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Mar 08, 2027 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
14-night panama canal cruise
$1,799
Holland America – Zaandam
4.5 (132)
Departs Mar 14, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
14-night panama canal cruise
$1,624
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
21-night panama canal cruise
$3,664
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
$1,314
Princess Cruises – Crown Princess
4.3 (211)
Departs Apr 04, 2027 from Fort Lauderdale, Florida
Up to 6 deals including an Avoya Exclusive
Secret Rate
17-night panama canal cruise
$1,724
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Apr 11, 2027 from Fort Lauderdale, Florida
Up to 4 deals including Avoya Exclusives
18-night panama canal cruise
$2,972
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Sep 18, 2027 from Los Angeles, California
Up to 4 deals
23-night panama canal cruise
$2,755
Princess Cruises – Coral Princess
4.4 (127)
Departs Sep 22, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
18-night panama canal cruise
$1,809
Princess Cruises – Coral Princess
4.4 (127)
Departs Sep 27, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
23-night panama canal cruise
$2,458
Princess Cruises – Star Princess
Departs Oct 03, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
20-night panama canal cruise
$2,189
Princess Cruises – Island Princess
4.2 (157)
Departs Oct 09, 2027 from Vancouver, BC, Canada
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,439
Princess Cruises – Star Princess
Departs Oct 10, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,559
Princess Cruises – Island Princess
4.2 (157)
Departs Oct 13, 2027 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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