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Best Panama Canal Cruises

Showing 51-75 of 229 results
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10-night panama canal cruise
$2,857
52% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 15, 2027 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,349
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Feb 03, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,502
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Feb 15, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,849
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Feb 17, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
12-night panama canal cruise
$1,889
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Mar 01, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
16-night panama canal cruise
$1,539
Princess Cruises – Island Princess
4.2 (157)
Departs Mar 02, 2027 from Los Angeles, California
Up to 7 deals including an Avoya Exclusive
Secret Rate
10-night panama canal cruise
$2,849
53% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Mar 05, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$2,334
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Mar 08, 2027 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
11-night panama canal cruise
$1,789
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Mar 13, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
10-night panama canal cruise
$2,952
52% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Mar 15, 2027 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,889
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Mar 24, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
16-night panama canal cruise
$1,549
Princess Cruises – Star Princess
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,509
Princess Cruises – Island Princess
4.2 (157)
Departs Apr 19, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
18-night panama canal cruise
$6,899
50% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Oct 24, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
10-night panama canal cruise
$3,099
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 06, 2028 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
10-night panama canal cruise
$3,099
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 16, 2028 from Panama City (Fuerte Amador), Panama
Up to 4 deals including an Avoya Exclusive
10-night panama canal cruise
$2,999
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Mar 05, 2028 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
10-night panama canal cruise
$2,999
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Mar 15, 2028 from Panama City (Fuerte Amador), Panama
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$1,339
Norwegian Cruise Line – Norwegian Jade
4.2 (153)
Departs Feb 27, 2026 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
17-night panama canal cruise
$1,189
Norwegian Cruise Line – Norwegian Jade
4.2 (153)
Departs Mar 11, 2026 from Lima (Callao), Peru
Up to 7 deals including an Avoya Exclusive
18-night panama canal cruise
$1,849
Norwegian Cruise Line – Norwegian Encore
4.4 (76)
Departs Apr 11, 2026 from Miami, Florida
Up to 9 deals including an Avoya Exclusive
10-night panama canal cruise
$795
Royal Caribbean – Serenade of the Seas
4.5 (214)
Departs Apr 25, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$1,499
Princess Cruises – Island Princess
4.2 (157)
Departs Sep 20, 2026 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
16-night panama canal cruise
$1,449
Princess Cruises – Sapphire Princess
4.3 (86)
Departs Nov 06, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
12-night panama canal cruise
$1,049
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 11, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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