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Best Panama Canal Cruises

Showing 26-50 of 214 results
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23-night panama canal cruise
$1,938
Princess Cruises – Star Princess
Departs Sep 27, 2026 from Vancouver, BC, Canada
Up to 4 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,799
Princess Cruises – Coral Princess
4.4 (126)
Departs Sep 29, 2026 from Los Angeles, California
Up to 3 deals including an Avoya Exclusive
Secret Rate
17-night panama canal cruise
$1,610
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Oct 01, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
16-night panama canal cruise
$2,179
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 13, 2026 from Los Angeles, California
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
19-night panama canal cruise
$2,279
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 13, 2026 from Los Angeles, California
Up to 8 deals including an Avoya Exclusive
16-night panama canal cruise
$1,667
Princess Cruises – Sapphire Princess
4.3 (86)
Departs Nov 06, 2026 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
12-night panama canal cruise
$960
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 11, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$1,789
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Nov 18, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
12-night panama canal cruise
$1,021
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 23, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$2,279
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Nov 23, 2026 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
16-night panama canal cruise
$1,299
Princess Cruises – Crown Princess
4.3 (211)
Departs Dec 03, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,859
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Dec 04, 2026 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
Avoya Exclusive Rate
12-night panama canal cruise
$1,200
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 17, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$1,689
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Jan 02, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
10-night panama canal cruise
$3,149
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 05, 2027 from Miami, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
15-night panama canal cruise
$6,210
55% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Jan 06, 2027 from Miami, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,279
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Jan 10, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,769
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Jan 13, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
10-night panama canal cruise
$3,249
50% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 15, 2027 from Panama City (Fuerte Amador), Panama
Up to 5 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,687
Princess Cruises – Island Princess
4.2 (157)
Departs Jan 29, 2027 from San Diego, California
Up to 6 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,430
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Feb 03, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$1,769
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Feb 06, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
12-night panama canal cruise
$1,504
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Feb 15, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,849
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Feb 17, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
16-night panama canal cruise
$1,537
Princess Cruises – Island Princess
4.2 (157)
Departs Mar 02, 2027 from Los Angeles, California
Up to 7 deals including an Avoya Exclusive
Secret Rate

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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