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Best Panama Canal Cruises

Showing 26-50 of 229 results
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22-night panama canal cruise
$1,899
Norwegian Cruise Line – Norwegian Encore
4.4 (76)
Departs Apr 11, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
20-night panama canal cruise
$1,599
Princess Cruises – Star Princess
Departs Apr 13, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
17-night panama canal cruise
$1,937
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Apr 13, 2026 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
10-night panama canal cruise
$1,650
75% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Apr 14, 2026 from Miami, Florida
Up to 6 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$4,017
Princess Cruises – Grand Princess
4.3 (137)
Departs Apr 16, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
18-night panama canal cruise
$1,489
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 25, 2026 from Miami, Florida
Up to 9 deals including an Avoya Exclusive
15-night panama canal cruise
$1,489
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 25, 2026 from Miami, Florida
Up to 9 deals including an Avoya Exclusive
22-night panama canal cruise
$1,983
Princess Cruises – Coral Princess
4.4 (126)
Departs Sep 23, 2026 from Vancouver, BC, Canada
Up to 4 deals including an Avoya Exclusive
Secret Rate
23-night panama canal cruise
$2,597
Princess Cruises – Star Princess
Departs Sep 27, 2026 from Vancouver, BC, Canada
Up to 4 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,399
Princess Cruises – Coral Princess
4.4 (126)
Departs Sep 29, 2026 from Los Angeles, California
Up to 4 deals including an Avoya Exclusive
Secret Rate
17-night panama canal cruise
$1,799
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Oct 01, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
16-night panama canal cruise
$1,649
Princess Cruises – Star Princess
Departs Oct 04, 2026 from Los Angeles, California
Up to 4 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,049
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Oct 30, 2026 from Fort Lauderdale, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$1,919
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Nov 18, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
12-night panama canal cruise
$1,099
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Nov 23, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$2,091
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Nov 23, 2026 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
16-night panama canal cruise
$1,429
Princess Cruises – Crown Princess
4.3 (211)
Departs Dec 03, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,399
Princess Cruises – Island Princess
4.2 (157)
Departs Dec 12, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,149
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 17, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
16-night panama canal cruise
$1,379
Princess Cruises – Island Princess
4.2 (157)
Departs Dec 28, 2026 from Los Angeles, California
Up to 5 deals including an Avoya Exclusive
Secret Rate
11-night panama canal cruise
$1,689
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Jan 02, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
10-night panama canal cruise
$2,905
52% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Jan 05, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
15-night panama canal cruise
$5,420
55% Off List
Oceania Cruises – Vista
4.7 (37)
Departs Jan 06, 2027 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,268
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Jan 10, 2027 from Fort Lauderdale, Florida
Up to 7 deals including an Avoya Exclusive
Secret Rate
12-night panama canal cruise
$1,799
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Jan 13, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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