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Best Panama Canal Cruises

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27-night panama canal cruise
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Holland America – Zuiderdam
4.3 (156)
Departs Feb 15, 2026 from San Diego, California
Up to 1 deal including an Avoya Exclusive
48-night panama canal cruise
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Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 09, 2026 from Papeete (Tahiti), French Polynesia
Up to 2 deals including Avoya Exclusives
38-night panama canal cruise
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Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 19, 2026 from Papeete (Tahiti), French Polynesia
Up to 2 deals including Avoya Exclusives
19-night panama canal cruise
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Seabourn – Seabourn Quest
4.6 (43)
Departs Apr 07, 2026 from Long Beach, California
Up to 2 deals including Avoya Exclusives
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Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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