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Best Panama Canal Cruises

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10-night panama canal cruise
$2,275
67% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Mar 25, 2026 from Tampa, Florida
Up to 6 deals including an Avoya Exclusive
16-night panama canal cruise
$1,989
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Oct 07, 2026 from Los Angeles, California
Up to 9 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
$2,358
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 13, 2026 from Los Angeles, California
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
19-night panama canal cruise
$2,396
Norwegian Cruise Line – Norwegian Bliss
4.0 (125)
Departs Oct 13, 2026 from Los Angeles, California
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
12-night panama canal cruise
$1,774
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Nov 06, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
11-night panama canal cruise
$1,601
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Nov 29, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
$1,859
Norwegian Cruise Line – Norwegian Star
4.1 (162)
Departs Dec 04, 2026 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
Avoya Exclusive Rate
12-night panama canal cruise
$1,133
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Dec 05, 2026 from Fort Lauderdale, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
11-night panama canal cruise
$1,601
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Dec 10, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
18-night panama canal cruise
$4,289
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Dec 18, 2026 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
$1,349
Princess Cruises – Island Princess
4.2 (157)
Departs Jan 13, 2027 from Fort Lauderdale, Florida
Up to 8 deals including Avoya Exclusives
Secret Rate
Avoya Exclusive Rate
12-night panama canal cruise
$1,183
Princess Cruises – Caribbean Princess
4.1 (256)
Departs Jan 22, 2027 from Fort Lauderdale, Florida
Up to 8 deals including Avoya Exclusives
Secret Rate
Avoya Exclusive Rate
12-night panama canal cruise
$1,922
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Jan 25, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
11-night panama canal cruise
$1,749
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Feb 06, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
16-night panama canal cruise
$1,349
Princess Cruises – Island Princess
4.2 (157)
Departs Feb 14, 2027 from Fort Lauderdale, Florida
Up to 8 deals including Avoya Exclusives
Secret Rate
Avoya Exclusive Rate
16-night panama canal cruise
$1,349
Princess Cruises – Island Princess
4.2 (157)
Departs Mar 18, 2027 from Fort Lauderdale, Florida
Up to 8 deals including Avoya Exclusives
Secret Rate
Avoya Exclusive Rate
16-night panama canal cruise
$1,399
Princess Cruises – Island Princess
4.2 (157)
Departs Apr 03, 2027 from Los Angeles, California
Up to 8 deals including Avoya Exclusives
Secret Rate
Avoya Exclusive Rate
11-night panama canal cruise
$1,769
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Apr 05, 2027 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
Avoya Exclusive Rate
15-night panama canal cruise
$2,710
Celebrity Cruises – Celebrity Summit
4.5 (379)
Departs Apr 18, 2027 from Tampa, Florida
Up to 5 deals including an Avoya Exclusive
Avoya Exclusive Rate
15-night panama canal cruise
$1,809
Norwegian Cruise Line – Norwegian Joy
4.1 (96)
Departs Apr 21, 2027 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
12-night panama canal cruise
$2,572
Norwegian Cruise Line – Norwegian Sun
4.1 (156)
Departs Dec 21, 2026 from Miami, Florida
Up to 8 deals including an Avoya Exclusive
Avoya Exclusive Rate
14-night panama canal cruise
$9,799
62% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Feb 23, 2027 from Miami, Florida
Up to 5 deals including Avoya Exclusives
11-night panama canal cruise
$33,886
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Mar 16, 2026 from Fort Lauderdale, Florida
Up to 6 deals including Avoya Exclusives
10-night panama canal cruise
$1,870
72% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Apr 04, 2026 from Panama City (Fuerte Amador), Panama
Up to 6 deals including an Avoya Exclusive
Secret Rate
27-night panama canal cruise
$2,018
Princess Cruises – Grand Princess
4.3 (137)
Departs Apr 05, 2026 from San Juan, Puerto Rico
Up to 5 deals including an Avoya Exclusive
Secret Rate
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Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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